Edit: Zoning/HOAs
I must ensure that the area I'm in allows for home business. I do my leatherwork out of my home shop. Any known areas that frown upon this? Of course, we'll be certain to inquire about it with an agent.
I think the only issues you'll have is if it's a business that has customers/traffic visiting your house. Even in the stricktest areas, tons of people run businesses out of their home.
A neighbor started a cabinetry/woodworking business in his garage. It was set up like a shop. Very unusual for around here but it wasn't a a problem. He's now in a building with room on a couple acres not far from here. Several others office or run side businesses from home.