Ankle holsters work with very small guns and long pants. They suck when you're not sitting down. Difficult to get to, long draw time, and more vulnerable to someone taking your gun from you in a grappling situation, especially on the ground.Ankle holsters and shoulder holsters are great for vehicle work.
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Shoulder holsters are great for cold weather, where you can wear a jacket to conceal them. Contrary to Don Johnson supposedly concealing a Bren Ten under his sport coat in the 1980s Miami heat, they're not so great for the Texas summer months.