Carbon buid up in the primer pocket can cause high primers, but can also act as a shock absorber to absorb part of the firing pin strike energy leading to light indent misfires. I prefer to clean everytime except I have come into a large quantity of Speer RHT brass. The lead free priming compound leaves very little residue. I have not been cleaning those for the first re-load. Commercially available primers are pretty dirty, I clean after that first re-load.