Purpose of the gun in question is really important to consider. For target shooting and some light deer & varmit hunting the 22-250 is VERY effective. It is a flat shooting bullet and has plenty of killing power for the deer around here, certainly any varmit. I regret selling mine and may pick up another soon.
I built a custom varmint rifle on a 1936 Mauser action with a German Reitz barrel in 22-250. It sits in a Fajen full beavertail black walnut stock, 26" full bull barrel and wears a Bushnell 4x16 scope. The thing weighs almost 11 pounds and from my Harris Bi-pod, it has almost no recoil.
Love the round! Very accurate and anchors the average coyote or bobcat real fast. Never hot anything bigger than a large coyote...I have a 270 and 30-06 for deer and pigs and don't consider any 22 centerfire for deer or bigger game, sorry.
Its a great round, if you want to reach out there. The damage done by the 55gr Ballistic Tip is...well...impressive!
I am with brickboy. I have a Remington 700v in 22-250. bull barell with synthetic stock, bipod, and a custom painted reaper on the stock. I love it for varmits and target shooting. I have a 30-06 and a 25-06 for deer and other larger game. As for the 55gr. ballistic tips, yep!
the 22-250 is great, guys used them for deer back in ND, where a fawn there is like "thats a nice doe" hear. I used mine for praire dogs and coyotes ect. I liked 50 grain blitz kings and 36 grains of imr 4895. My rifle is a M 70 26 stainless heavy barrel. The reason I went with 50's over 55's was for 2 reasons; 1 they grouped better and 2 they recoiled less, meaning with that heavy rifle you could see the impact on pd's.